• CSL Behring (Pasadena, CA)
    …Overview: This role will lead a project-specific CMC team(s) within CSL Behring's Gene Therapy Product pipeline. The primary responsibility is to ensure a ... recent experience in validation and characterization studies for the registration of Viral vector , cell based therapeutics or recombinant proteins * Experience… more
    ZipRecruiter (05/01/20)
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  • CSL Behring (Pasadena, CA)
    …Overview: This role will lead a project-specific CMC team(s) within CSL Behring's Gene Therapy Product pipeline. The primary responsibility is to ensure a ... recent experience in validation and characterization studies for the registration of Viral vector , cell based therapeutics or recombinant proteins Experience in… more
    Jobs2Careers (05/20/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …various molecular biology and cell-based assays to support the process development of gene therapy products across all therapeutic areas. The selected candidate ... to the development of new assays and methods to support process development of novel gene therapy programs. The candidate must be able to efficiently develop and… more
    Spark Therapeutics (03/25/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …execute experiments efficiently, perform data analysis to support multiple gene therapy projects. Participate process characterization/validation work, ... > 3-4 years biotechnology or pharmaceutical industry experience. * Experience with viral vector production and characterization is preferred Competencies *… more
    Spark Therapeutics (03/25/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …experience is required. Experience in formulation and fill/finish process development for gene therapy and/or biological molecules is required. Experience with ... record and/or patent filing is plus. Working knowledge and skills for viral vector or vaccine purification is a plus. Competencies Strong organizational skills… more
    Spark Therapeutics (05/03/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …understanding of molecular biology and cell culture. Experience in viral vaccine or viral vector gene therapy manufacturing is a plus Competencies ... Excellent written and communication skills and attention to detail Ability to work independently Demonstrated strong organizational skills including ability to prioritize tasks and adhere to agreed timelines Strong interpersonal skills and ability to… more
    Spark Therapeutics (04/28/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …Chemistry or Biochemistry and > 3-4 years biotechnology experience. Experience with viral vector production and characterization is preferred. Key Skills, ... and interact with multi-disciplinary research teams at Spark. Knowledge of gene therapy is preferred, but not required. Complexity and Problem Solving On… more
    Spark Therapeutics (04/09/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …laboratory automation to support analytical testing is a plus. * Experience with viral vector production and characterization is preferred Competencies * Strong ... biotech start-up environment and interact with multi-disciplinary research teams at Spark. * Knowledge of gene therapy is preferred, but not required. more
    Spark Therapeutics (03/25/20)
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  • Spark Therapeutics (Providence, RI)
    …culture seed trains that are robust, reproducible and scalable for recombinant adeno-associated viral vector (rAAV) production processes up to and ≥ 200L. ... bioreactors and/or benchtop stirred tank bioreactors is essential. Experience with viral vector production preferred. Experience with development and… more
    Spark Therapeutics (04/07/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …quality-by-design and risk-based approach to the development of recombinant adeno-associated viral vector (rAAV) production processes that are robust, ... receiving entities (internal MFG, CDMO, CMO, etc.) is preferred. Experience with viral vector production is preferred. Experience with development and… more
    Spark Therapeutics (03/30/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …prediction and correlating these readouts with the clinical outcome of gene therapy . Incumbent oversees strategic planning, execution, and reporting ... immunogenicity and strategies to modulate immune responses in the context of gene therapy ; leads a group of Scientists and Research Associates to support… more
    Spark Therapeutics (05/10/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …of the Ocular Research Group and participates in the development of Spark’s Ocular gene therapy products. She/he will actively participate in the development of ... concept and IND-enabling studies. She/he will lead efforts in vector design and cloning, identification of efficacy readouts in...for: Developing strategies to optimize potency and efficacy of gene therapy vectors. Creating novel approaches to… more
    Spark Therapeutics (03/13/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …clinical setting. She/he coordinates cross-functional efforts within our R&D organization to advance gene therapy programs. The Research Scientist is a member of ... for: Developing strategies to optimize potency and efficacy of gene therapy vectors. Creating novel approaches to enhance specificity, regulatability, and… more
    Spark Therapeutics (04/06/20)
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  • Spark Therapeutics (Philadelphia, PA)
    gene transfer Developing strategies to optimize potency and efficacy of gene therapy vectors. Creating novel approaches to enhance specificity, tolerability ... and durability of gene therapy vectors. Designing and supporting in...Excellent communication skills (both oral and written). Experience with vector design, cloning, ocular gene transfer, and… more
    Spark Therapeutics (03/13/20)
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  • Careerbuilder-US (Framingham, MA)
    …formulation and process development of biological modalities such as monoclonal antibodies, enzymes, viral gene therapy , etc Understanding of formulation and ... be the lead contributor to a Biopharmaceutical Drug Product development project (including Gene Therapy , Protein therapeutics, etc) and will be responsible for… more
    Neuvoo (05/27/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …and minimalizing the risk of potential immune response in subjects of gene therapy trials. Responsibilities: 40% Provide strategic and scientific leadership ... testing laboratory A background in immunomodulation and risk mitigation in AAV gene therapy is preferred Competencies: A background in immunology and AAV gene more
    Spark Therapeutics (04/27/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …molecular, cellular and in vitro/in vivo techniques for hepatic gene therapy programs. Developing strategies to support liver-specific delivery and transgene ... Liver Pre-Clinical Research Lead position supports translational research of gene therapies targeting the liver, including: Target...plus years of hands-on experience in the field of gene therapy or a relevant field of… more
    Spark Therapeutics (05/22/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …to engineer capsids, therapeutic proteins/antibodies in support of current and future gene therapy programs. Providing leadership within a group of ... 30% - Devise and evaluate novel strategies to address limitations of current gene therapy approaches through protein design, engineering and evolution. Design… more
    Spark Therapeutics (05/18/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …support of developing capsids and therapeutic proteins for current and future gene therapy programs. Collaborating with other Translational Research Scientists ... the design and evaluation of novel strategies to address limitations of current gene therapy approaches through protein design, engineering and evolution. This… more
    Spark Therapeutics (05/15/20)
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  • Spark Therapeutics (Philadelphia, PA)
    …Discovery Research Group and participates in the development of Spark’s CNS-targeted gene therapy products. She/he will actively participate in the development ... using a combination of molecular, cellular and in vitro/in vivo techniques for CNS gene therapy programs Design and construction of optimized gene expression… more
    Spark Therapeutics (05/12/20)
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