- University of Colorado (Aurora, CO)
- …of pluripotent stem cells into a variety of cell types, and CRISPR-Cas9-mediated gene targeting . Laboratory duties will involve receiving laboratory reagents and ... including melanoma and other skin cancers, and development of approaches to gene therapy in the skin. The Dermatopathology unit provides pathology services to… more
- Lilly (Indianapolis, IN)
- …includes active investments in Oligonucleotide development, nanomedicines for tissue specific targeting and other gene delivery strategies. The drug product ... team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery. We are seeking highly motivated professionals with an experience in developing… more
- Lilly (Indianapolis, IN)
- …includes active investments in Oligonucleotide development, nanomedicines for tissue specific targeting and other gene delivery strategies. The drug product ... team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery. We are seeking highly motivated professionals with extensive experience in… more
- Lilly (Indianapolis, IN)
- …includes active investments in Oligonucleotide development, nanomedicines for tissue specific targeting and other gene delivery strategies. The drug product ... team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery. We are seeking highly motivated professionals with an experience in developing… more
- Rush University Medical Center (Chicago, IL)
- …will lead research efforts on human iPSC-based disease modeling or/and CRISPR gene perturbations. The job will perform experiments, analyze data, compile results, ... brain organoid cultures, high-content imaging, molecular biology, viral packaging, CRISPR gene perturbations and data analysis. Exemplifies the Rush mission, vision… more
- Editas Medicine (Cambridge, MA)
- …allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing. We believe our people are at the core of everything we do, ... must have a proven track record in the discovery and development of drugs targeting diseases of non-CNS/peripheral tissues at least through IND, with more than one… more
- UCLA Fielding School of Public Health (Los Angeles, CA)
- …analyze data and lead projects in vascular biology, focusing on high-resolution gene expression profiling techniques. Responsibilities: + Collaborate with the PI and ... the lab. + Conduct innovative research in vascular biology, specifically targeting intracranial artery disease. + Utilize techniques like western blotting, qPCR,… more
- University of Rochester (Rochester, NY)
- …coordination and execution of experiments to establish the function and therapeutic targeting of various oncogenes of interest in myeloid leukemia to the principal ... immunohistochemistry. + Animal experiments, breeding and maintenance of wild-type and gene specific knockout mice under development. Xenografting cancer cells in… more
- Emory Healthcare/Emory University (Atlanta, GA)
- …for mRNA and other RNA-based drugs. The drugs may consist of vaccines, gene replacement therapies, mRNA-encoded antibodies, CRISPR gene editing therapies, and ... programs will be on extrahepatic delivery, and will therefore require both de- targeting the liver and increasing delivery to other tissues. Prepares and publishes… more
- Pfizer (San Diego County, CA)
- …adaptive and acquired resistance nodes and networks of small molecules targeting oncogenic signaling pathways to inform mitigation strategies for these tumor ... CRISPR, DTAG, etc). Experience in use of CRISPR-based techniques for gene knockout, gene editing. + Excellent organization and planning ability, good verbal and… more
- Pfizer (San Diego County, CA)
- …strong track record in cancer drug discovery/translational research and the targeting of epigenetic pathways by small-molecule inhibitors. + Expertise in techniques ... of IND study reports + Experience in use of CRISPR-based techniques for gene knockout, gene editing and as well as working knowledge of pooled CRISPR -based… more
- University of Washington (Seattle, WA)
- …on the development, characterization, and refinement of vaccines and therapeutics targeting infectious diseases and cancers. This position will support projects ... Mouse handling, injections (IM, SQ, IP, RO), ear punching, vaccinations ( Gene Gun, IM, Intranasal, among other routes), challenge inoculations (influenza,… more
- University of Utah (Salt Lake City, UT)
- …keratan sulfates. * Chemical tools for studying and therapeutically targeting phosphorylation-dependent cellular signaling pathways. * Medicinal chemistry and ... biology targeted toward enzymes involved in immunology, neurological development, cancer, gene regulation, etc. * New tools for studying the biosynthesis,… more
- University of Colorado (Aurora, CO)
- …of our studies is to identify mechanisms of resistance to therapies targeting these pathways. The postdoctoral fellow will use unbiased approaches, including ... world, that have been molecularly characterized by genome-wide copy number and gene expression, histology, and mutations. Together, these tools and approaches will… more
- Burns & McDonnell (Columbus, OH)
- …and knowledge of life sciences markets and processes (fermentation, cell / gene therapy, API, blood products, purification, fill / finish, medical devices, etc) ... critical project objectives + Own the development of direct reports including targeting work for individual team members to expand their capabilities + Stay… more
- Pfizer (New York, NY)
- …is a novel agent for hemophilia that promotes clotting activity by targeting an anticoagulant protein called tissue factor pathway inhibitor (TFPI). It is ... with marketers for the existing Hemophilia factor portfolio and the near-term Gene Therapy pipeline to build a cohesive and integrated Hemophilia portfolio… more
- University of Colorado (Aurora, CO)
- …generate different type of organoids + Design and execute CRISPR/Cas9-based gene editing experiments for validating disease-causing mutations. + Design and execute ... will participate in drug-screening studies to develop therapies for EDS by targeting pathways involved in collagen assembly and inflammation. The ideal applicant… more
- Johns Hopkins University (Baltimore, MD)
- …practical relationship to essential techniques in modern drug discovery, drug targeting and delivery, cellular and tissue analysis and characterization, and ... not be limited to, PCR optimization, quantitative real-time PCR, and control of gene expression by DNA sequencing in the clinical setup. The essential concepts… more
- University of Utah (Salt Lake City, UT)
- …ex vivo retina, calcium fluorescence imaging, virus-mediated cell targeting , immunohistochemistry, large-scale data analysis, and computational modeling. Successful ... preferred. Experience working with virus and virus mediated cell-, circuit- and gene manipulations is not required but would be considered advantageous. In… more
- Danaher Corporation (Washington, DC)
- …biological research to developing innovative vaccines, new medicines, and cell and gene therapies. At Cytiva you will be able to continuously improve yourself ... portfolio: developing new markets, succeeding in understanding assigned territory, targeting market segments, and introducing new products and workflow solutions… more