- Merck & Co. (South San Francisco, CA)
- …environment.Broad knowledge and first-hand experience in in vitro and in vivo models of metabolic diseases & obesity required.Solid understanding ... be responsible for overseeing and facilitating the research in metabolic diseases & obesity and its co-morbidities, in the...the development and implementation of in vitro and in vivo assays to conduct investigation of disease biology to… more
- University of Miami (Miami, FL)
- …protein expression analysis, imaging, and cell-based assays. + Experience with in vivo metabolic studies using rodent models, including handling, dosing, tissue ... involves the development and optimization of both in vitro and in vivo models to investigate diabetes-related disease mechanisms and to evaluate potential… more
- Cedars-Sinai (Los Angeles, CA)
- …Cancer Center. Our research group has an established track record in the study of metabolic pathways using in vivo and ex vivo multi-omics approaches, ... unique opportunity within the research group is to establish in vivo mouse models to study metabolic changes in the heart during cancer. Currently, a particular… more
- Auburn University (Auburn, AL)
- …and participate in activities associated with the Boshell Diabetes and Metabolic Disease Research Program at Auburn University. The fundedNIH project ... models of obesity, including but not limited to: genotyping animals; assessing metabolic phenotypes; and harvesting tissues and whole blood 3. Performing cell and… more
- Merck (South San Francisco, CA)
- …Obesity will be responsible for overseeing and facilitating the research in metabolic diseases & obesity and its co-morbidities, in the Cardiometabolic Disease (CMD) ... + Lead and help shape the departmental strategy in metabolic disease research & obesity. + Implement the strategy...of a robust pipeline of therapeutic targets for treating metabolic diseases & obesity and its co-morbidities. + Manage… more
- University of Pennsylvania (Philadelphia, PA)
- …and resources, and much more. Posted Job Title Research Manager, Rodent Metabolic Phenotyping Core Job Profile Title Manager D, Research Job Description Summary ... of the Institute for Diabetes, Obesity, and Metabolism's Rodent Metabolic Phenotyping Core; provide daily management for all activities...to day management of core staff performing complex in vivo studies in rodent models for core clients. 2.… more
- Bristol Myers Squibb (Princeton, NJ)
- …hands-on metabolite profiling and characterization of drug candidates in vitro and in vivo to understand metabolic pathways to support drug discovery and ... oversight of cold and radiolabeled in vitro and in vivo preclinical and clinical biotransformation studies for small molecules...product profiles, and to integrate in vitro and in vivo data for presentations. + Evaluate and implement innovative… more
- Rhythm Pharmaceuticals (Boston, MA)
- …assays and in vivo PK/PD experiments in different animal models of metabolic and genetic diseases of obesity + Significant experience in managing CROs across the ... the design, development, and execution of in vitro pharmacology assays and in vivo studies in animal models of disease to assess the biological activity, mechanism… more
- Mount Sinai Health System (New York, NY)
- …and utilizing both _in vitro_ and _in vivo_ metabolomics, we will explore the metabolic basis for tumor growth and how metabolic factors shape the immune ... The mission of our lab is to understand the metabolic factors that fuel immunity and cancer. Applying cutting-edge...the immune system where we strive to expose novel metabolic vulnerabilities that can be utilized to limit disease… more
- UCLA Fielding School of Public Health (Los Angeles, CA)
- …such spectral flow cytometry, proteomic assays, confocal microscopy, and in vivo imaging in conditional knockout mouse models; 2) performing unbiased screens ... and how these affect cellular responses to stress; and, 4) developing new ex vivo models from human lung specimens for investigating the pathogenesis of lung injury… more
- Sanofi Group (Cambridge, MA)
- …achieve go/no-go decisions + Design and conduct in vitro and in vivo mechanism-of-action, proof-of-concept, and biomarker studies to validate targets and evaluate ... readouts + Design and conduct in vitro and in vivo studies to evaluate the pharmacology and efficacy of...ocular disease processes, such as cell death, barrier function, metabolic and oxidative stress, lipid metabolism, tissue remodeling, and… more
- University of Southern California (Los Angeles, CA)
- …researcher who is interested in the field of liver disease (eg metabolic liver disease, viral hepatitis, liver inflammation, and hepatic immunity). The candidate ... is expected to have significant experience with in vitro and vivo experiments, including but not limited to primary cell isolation/culture, general molecular… more
- Mount Sinai Health System (New York, NY)
- …to develop efficient and safe interventions for preventing and treating metabolic diseases. Her recent publications include Cell Metabolism, Journal of Hepatology, ... technologies used in the lab include transgenic mouse models, human genetics, metabolic studies, stem cell biology, next generation sequencing, and a variety of… more
- Regeneron Pharmaceuticals (Hawthorne, NY)
- …receptor agonists, etc.) across research areas such as oncology, metabolic disease/obesity, infectious disease, immunology and inflammation, neuroscience, and ... ophthalmology. Cultural fit with the Regeneron cross-functional teams will be a key driver for success. The R&D Chemistry team is primarily composed of synthetic organic, medicinal chemistry and bioconjugation scientists that work in a highly collaborative… more
- UCLA Fielding School of Public Health (Los Angeles, CA)
- …with a net decline in long-term repopulation capacity of HSPCs after ex vivo culture and genetic manipulation will be performed. The fundamental aspects of the ... Kinetics of quiescency exit and cell cycle progression; (ii) Metabolic preferences, and iii) Epigenetic modifications of current ex... preferences, and iii) Epigenetic modifications of current ex vivo culture systems and the novel in vitro culture… more
- Florida Atlantic University (Jupiter, FL)
- …and tissue imaging techniques to study mechanisms of neuronal dysfunction. In Vivo Studies: Conducting research using mouse models to explore mechanisms of disease ... progression. Experimental Procedures: Cell culture and analysis of metabolic and functional state; cell imaging; iPSC-derived brain cells; western blots;… more
- Lilly (Boston, MA)
- …+ Design and execute an experimental program aimed at understanding how alterations in metabolic activity alter autophagy in the brain at a cellular level and how ... neuroscience, molecular biology or related life sciences) + 1+ years of in- vivo modeling experience within Industry or Academic lab **Additional Qualifications:** +… more
- Cleveland Clinic (Cleveland, OH)
- …cell activation during immune responses. Research focuses on the biochemical and metabolic pathways involved in B cell activation and plasma cell differentiation, ... of improved therapies and vaccines and address the challenges metabolic disorders pose to human health. As a Senior...supporting general research activities, including in vitro and in vivo immunological assays. This role is essential to advancing… more
- Mount Sinai Health System (New York, NY)
- …to residual cardiovascular disease risk. Using a combination of in vivo physiology, molecular biology, stable isotope tracer methodology and integrative multi-omics, ... we aim to define the critical metabolic pathways that underlie atherosclerotic plaque progression and vulnerability. We are currently focused on two integrated areas… more
- Amgen (Thousand Oaks, CA)
- …platforms **Cross-Functional Collaboration** : Partner closely with in vivo pharmacologists, protein biochemists, structural biologists, medicinal chemists, ... and/or related areas. + Deep technical expertise in signal transduction, metabolic regulation, and/or in vitro pharmacology. + Demonstrated creativity and scientific… more
