• Reactor (San Francisco, CA)
    A technology company focused on AI in San Francisco is seeking a Founding Infrastructure Engineer to design and scale their infrastructure for real-time AI ... role demands deep expertise in Kubernetes and cloud-native systems, partnering with ML engineers, and defining infrastructure growth strategies. You'll enjoy a… more
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  • Decagon AI, Inc. (San Francisco, CA)
    …how we work and grow as a team. About the Role Decagon is seeking a Founding Solutions Architect - Infrastructure , a foundational technical hire who will ... Even Better If You Have 2+ years of experience selling or architecting AI/ ML infrastructure solutions in enterprise environments. Experience working in a… more
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  • Reducto (San Francisco, CA)
    …up. You will architect and scale resilient systems for AI and ML workloads, automate cloud infrastructure , and implement monitoring and incident response ... investors like A16z, Benchmark, and First Round Capital, and are hiring a founding Infrastructure Engineer. The Opportunity As the first dedicated … more
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  • Recruiting From Scratch (San Francisco, CA)
    …modern ML approaches. Familiarity with production systems involving cloud infrastructure (AWS, GCP). Proficient in Python and frameworks like PyTorch. Capable of ... of audio AI. Their mission is to build best-in-class infrastructure and models for collecting and training on large-scale,...researchers with a proven track record in building scalable ML systems. You'll be working on cutting-edge technology in… more
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  • Hirewell (San Francisco, CA)
    …scale Experience with high-performance backend systems, modern frontend stacks, or AI/ ML pipelines Familiarity with GPU infrastructure , model inference ... Infrastructure : Cloud-native, edge compute, Docker, GPU orchestration, CDNs AI/ ML : Inference streaming, integration of video/image generation models, real-time… more
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  • Together For Talent (San Francisco, CA)
    Founding Software Engineer | AI for Supply Chain Automation Location: San Francisco, CA (On-site) Salary: $170K - $225K base + Equity Based in San Francisco, we're ... for granted. What's In It For You Be the founding engineer shaping a next‑generation AI platform from the...deploy autonomous AI agents for complex supply chain workflows. Architect scalable backend systems and real‑time interfaces for customers.… more
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  • Poesis (San Francisco, CA)
    …future hires. Responsibilities Architect , build, and maintain the core ML infrastructure for Poesis' investment platform. Develop reproducible pipelines for ... fund focused on reshaping how trading decisions are made. We're hiring our Founding ML Engineer, the first full-time machine learning hire who will turn research… more
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  • Motion Recruitment Partners LLC (San Francisco, CA)
    Founding Engineer - AI Startup (San Francisco, In-Office) An early-stage, venture-backed AI startup in San Francisco is hiring its first Founding Engineer . This ... product, this role offers significant impact and autonomy. What You'll Do Architect , build, and deploy end-to-end features across the stack-from backend services to… more
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  • Menlo Ventures (San Francisco, CA)
    …transform how enterprises manage their spend. Core Responsibilities Design and architect the foundational infrastructure for NegotiateAI's procurement platform, ... us. About this role This foundational teammate will build the infrastructure that powers our AI-driven procurement platform, enabling seamless data categorization… more
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  • Clipbook, Inc (San Francisco, CA)
    …Shape the future. As one of the very first backend engineers, you'll architect foundational services and data infrastructure that will define Clipbook's ... country. We will raise our Series A in early 2026. What You'll Do Architect & build core backend systems. Drive architectural decisions across our backend stack… more
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  • Asystem (San Francisco, CA)
    …scalable applications using Node.js, TypeScript, and Nuxt (Vue). System Architecture: Architect and manage robust database schemas with PostgreSQL and Supabase, ... ensuring data integrity and performance. Infrastructure & Operations: Manage deployments and background jobs using Render and Inngest, and assist in maintaining… more
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  • HRB (San Francisco, CA)
    …scale. As the first hire, the work this person does will become core infrastructure and strongly influence our engineering for years to come. This person will likely ... lead a team as we scale. Expected outcomes Architect and implement whole parts of the app from...Node.js Svelte for UI Swift/C++ for native applications & ML inference Some Python for machine learning prototyping, not… more
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  • Open Select (San Francisco, CA)
    …using Kubernetes and AWS for real-time voice processing Design and optimize ML infrastructure for training and inference across multiple regions Integrate ... Y Combinator, Emergence, and founders of Twilio, Affir ). As a Senior Infrastructure Engineer, you'll architect and scale distributed systems that power millions… more
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  • VibeCode (San Francisco, CA)
    …Background in security sandboxing or container isolation technologies Understanding of AI / ML infrastructure and model serving at scale Why Vibecode Impact : ... the systems that power millions of AI-generated applications. You'll architect the platform that securely runs thousands of user-created...no one has tackled before. Ownership : As a founding infrastructure engineer, you'll define our platform… more
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  • dimensioncap (San Francisco, CA)
    …setting out to re- architect drug discovery and save lives. The Chai founding team brought together leading researchers in this space and top silicon valley ... are hiring an engineer obsessed with building systems and infrastructure that are as simple as possible while being...have built services that developers love, moved and scaled AI/ ML systems into production, and can help us predict… more
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  • Sierra (San Francisco, CA)
    …also one of Google's earliest product managers and co‑creator of Google Maps. Before founding Sierra, Clay spent 18 years at Google, where he most recently led ... design teams for Google Workspace. What you'll do As a Software Engineer, Infrastructure at Sierra, you will be responsible for designing, building, and maintaining… more
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  • Axiom (San Francisco, CA)
    Charter: Be a founding member of a team setting out to build the first accurate AI systems for replacing lab and animal toxicity experiments with AI models What are ... finally works. What you will be doing: Define the core end-to-end ML /AI system: wetlab data creation and data cleaning/processing; model architecture, training, and… more
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  • context.ai (San Francisco, CA)
    …from the best What You'll Do t Context AI, Senior Software Engineers (MTS) architect and build the platform that powers AI agents executing complex, high-stakes work ... As a Senior MTS Engineer, you'll experience the autonomy and impact of a founding engineer with the resources, mentorship, and stability of a well-funded AI company.… more
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  • Activeloop Inc (Mountain View, CA)
    …Be Doing Architect and Develop: Design and build scalable backend infrastructure optimized for high-performance AI and ML workloads, ensuring robustness and ... and proven capabilities in architecting scalable platforms tailored for AI and ML workloads. As a core technical leader, you'll influence strategic decisions,… more
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  • Watneyrobotics (San Francisco, CA)
    …Watney Watney develops autonomous robots to enable the growth of critical infrastructure . Having recently raised $21 million in seed funding from Conviction, ... the foundational members of our Engineering team, you will architect and develop petabyte‑scale data pipelines for our fast‑growing...company, but in modern computing. Working directly with our founding team, this role is based onsite at our… more
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