• Principal Scientist - Clinical…

    Amgen (South San Francisco, CA)
    …Join us and transform the lives of patients while transforming your career. ** Principal Scientist - Clinical Pharmacology, Modeling & Simulation** **What you ... Clinical Pharmacology, Modeling & Simulation Department at Amgen is seeking a Principal Scientist . In this vital role, you will drive innovative modeling and… more
    Amgen (12/21/25)
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  • Associate Principal Scientist

    Merck (South San Francisco, CA)
    …seeking an exceptional and experienced scientist in the role of Associate Principal Scientist in the South San Francisco Discovery Biologics group. The ... qualified candidate will be a scientist with a breadth and depth of expertise in immunization-based antibody discovery, including but not limited to expertise in… more
    Merck (01/06/26)
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  • Sr Principal Scientist , AGI…

    Amazon (Sunnyvale, CA)
    Description As a Senior Principal Scientist in AGI, you will have deep subject matter expertise in the area of large language models and generative AI across ... to an executive level decision maker. Mentors and trains the research scientist community on complex technical issues. - Excellent written and spoken communication… more
    Amazon (01/02/26)
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  • Principal Scientist , Group Leader,…

    Genentech (South San Francisco, CA)
    **The Position** **The Opportunity** We are seeking an exceptional Principal Scientist (Group Leader) to join our world-class Antibody Engineering Department, ... areas + Drive innovation to solve them through antibody engineering Our new Scientist /Group Lead will help shape the future of our antibody drug capabilities and… more
    Genentech (12/06/25)
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  • Principal Scientist , Protein…

    Gilead Sciences, Inc. (Foster City, CA)
    …and engineering of large molecule drug candidates. We seek a highly motivated Principal Scientist to contribute to the engineering of Multispecific formats, ... novel antibody binding domains, fusion proteins (eg cytokines), as well as to the development of new, cutting-edge technologies. The successful candidate will independently oversee biologics projects from protein design to lead optimization, manage multiple… more
    Gilead Sciences, Inc. (01/05/26)
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  • Principal Scientist , Oncology…

    Gilead Sciences, Inc. (Foster City, CA)
    …our day and improving the lives of patients for generations to come. As a Principal Scientist of Tumor-Intrinsic Biology you will lead a discovery lab and ... collaborate across functions to pursue creative science, develop strategic initiatives, and evaluate external partnerships, in the service of discovering novel medicines that impact patients' lives. **Additional Key Responsibilities** Leadership + Mentor a… more
    Gilead Sciences, Inc. (12/20/25)
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  • Senior Principal Scientist

    Merck (South San Francisco, CA)
    **Job Description** **Senior Principal Scientist (Sr Director), Oncology Translational Science and Clinical Biomarkers:** Our Company's Oncology organization is ... dedicated to delivering breakthrough innovations that extend and improve the lives of cancer patients worldwide. Our team of dauntless, forward-thinking individuals achieves this through an unwavering commitment to supporting accessibility to medicine,… more
    Merck (01/06/26)
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  • Senior Principal Scientist , Peptide…

    Genentech (South San Francisco, CA)
    …We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist ) to join our innovative research and development team. ... This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics. The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide… more
    Genentech (11/06/25)
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  • Principal Scientist , Computational…

    Frontier Medicines (South San Francisco, CA)
    …Medicines is seeking a highly motivated individual to fill the position of Principal Scientist , Computational Chemistry. The successful candidate will play a ... leading role in developing medicinal chemistry optimization strategies for key drug discovery programs. This individual will review experimental results, develop SAR hypotheses for activity, selectivity, and properties, and make design suggestions to improve… more
    Frontier Medicines (11/04/25)
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  • Principal Scientist , Oncology…

    Gilead Sciences, Inc. (Foster City, CA)
    …possible, together. **Job Description** We are seeking a highly talented and motivated Principal Bioinformatics Scientist to take a lead role in statistical ... high-level decision-making on internal pipeline and external collaboration. The scientist will be responsible for developing and employing rigorous statistical… more
    Gilead Sciences, Inc. (01/06/26)
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  • Principal Applied Scientist , Amazon…

    Amazon (Palo Alto, CA)
    …what's possible with AI, join us in shaping the future of advertising. The principal scientist in this position will focus on designing, developing and launching ... of what's possible in these fields. Key job responsibilities As a Principal Applied Scientist for the team, you will drive appropriate technology choices for the… more
    Amazon (12/28/25)
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  • Principal Applied Scientist

    Amazon (Palo Alto, CA)
    …products that directly help them create, optimize, and grow their campaigns. As a Principal Scientist , you will play a critical role in elevating the team's ... AI, join us in shaping the future of advertising. Key job responsibilities The Principal Applied Scientist in Advertiser Guidance team will lead 50+ builders in… more
    Amazon (10/25/25)
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  • Principal Applied Scientist , AGI…

    Amazon (Sunnyvale, CA)
    Description As a Principal Scientist within the Artificial General Intelligence (AGI) organization, you are a trusted part of the technical leadership. You bring ... to an executive level decision maker. Mentors and trains the research scientist community on complex technical issues. Excellent written and spoken communication… more
    Amazon (10/30/25)
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  • Principal Data Scientist

    Microsoft Corporation (Mountain View, CA)
    **Overview** The Bing organization is looking for a ** Principal Data Scientist ** . The team is pushing the boundaries regarding our understanding for how users ... opportunity to make solid, and even multiplicative impact on the org. As a Principal Data Scientist in this team, you will have the chance to work on and deliver… more
    Microsoft Corporation (12/17/25)
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  • Principal Data Scientist , AI…

    Capital One (San Jose, CA)
    Principal Data Scientist , AI Foundations Data is at the center of everything we do. As a startup, we disrupted the credit card industry by individually ... 200 company and a leader in the world of data-driven decision-making. As a Data Scientist at Capital One, you'll be part of a team that's leading the next wave… more
    Capital One (11/04/25)
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  • Principal Data Scientist , Agentic…

    Amazon (Mountain View, CA)
    Description AWS is seeking an exceptional Principal Data Scientist to join our Agentic AI ProServe Experience (APEX) team. This role calls for an individual ... for business application Preferred Qualifications - 8+ years of data scientist or similar role involving data extraction, analysis, statistical modeling and… more
    Amazon (01/14/26)
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  • Sr Principal Data Scientist (Prisma…

    Palo Alto Networks (Santa Clara, CA)
    …ensuring a formidable security posture from development through runtime. As a Senior Principal Data Scientist you will drive research on cutting-edge areas, ... ML systems. + Cross-Functional Vision: Act as a key technical liaison to other principal engineers, architects, and product leaders to shape the future of the Prisma… more
    Palo Alto Networks (12/18/25)
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  • Principal Applied Scientist - AI…

    General Motors (Mountain View, CA)
    …manipulation, autonomy, and simulation challenges at an industrial scale. As a Principal Applied Scientist , you will define technical direction, create ... breakthrough robot learning methodologies, and drive the execution of large-scale initiatives that deliver end-to-end manipulation policies. You will architect new model families, lead cross-functional research efforts, and guide teams in transitioning… more
    General Motors (01/09/26)
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  • Principal Data Scientist

    Intuit (Mountain View, CA)
    …cross-functional collaboration, all aimed at uncovering and scaling growth opportunities. As a Principal Data Scientist , you will operate at a senior technical ... level as an individual contributor, partnering closely with peers and leaders alike to identify, execute, and iterate on high-impact growth initiatives. Your role is pivotal in leveraging advanced data science techniques, including causal inference-to unlock… more
    Intuit (10/30/25)
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  • Principal Applied Scientist

    Amazon (Santa Clara, CA)
    …logistics through advanced AI and foundation models. We are seeking an exceptional Principal Applied Scientist to help develop innovative foundation models that ... enable delivery of billions of packages worldwide. In this role, you'll combine highly technical work with scientific leadership, ensuring the team delivers robust solutions for dynamic real-world environments. Your team will leverage Amazon's vast data and… more
    Amazon (12/23/25)
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