• Merck & Co. (South San Francisco, CA)
    …Sciences (DPS) group based in South San Francisco, CA is seeking an Principal Scientist with small molecule and peptide experience.DPS is a multi-disciplinary ... the progression of clinical candidate selection including Safety Assessment, Process Research, Medicinal Chemistry , Analytical Chemistry , and Drug Metabolism… more
    HireLifeScience (11/08/25)
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  • Principal Scientist

    J&J Family of Companies (San Diego, CA)
    …more at https://www.jnj.com/innovative-medicine **We are searching for the best talent for a** ** Principal Scientist , Medicinal Chemistry ** **to be ... position, the successful candidate will partner with both internal and external medicinal chemistry teams to generate innovative solutions to synthetic and… more
    J&J Family of Companies (09/12/25)
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  • Principal Scientist I / II,…

    Schrodinger (San Diego, CA)
    We're looking to hire a ** Principal Scientist in Medicinal Chemistry ** to join us in our mission to discover and develop drugs that improve human health ... qualifications. **Who will love this job:** + A passionate scientist with a robust background in structure-based drug design...a medicinal chemist + Support and execute medicinal chemistry strategies to deliver high quality… more
    Schrodinger (10/11/25)
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  • Senior Principal Scientist

    Schrodinger (San Diego, CA)
    We're looking to hire a **Senior Principal Scientist ** or **Director of Medicinal Chemistry ** to join us in our mission to discover and develop drugs ... discovery programs in effective collaboration with cross-functional teams + Execute medicinal chemistry strategies to deliver high-quality clinical candidates +… more
    Schrodinger (10/11/25)
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  • Principal Scientist , Computational…

    Frontier Medicines (South San Francisco, CA)
    …Medicines is seeking a highly motivated individual to fill the position of Principal Scientist , Computational Chemistry . The successful candidate will play ... a leading role in developing medicinal chemistry optimization strategies for key drug discovery programs. This individual will review experimental results,… more
    Frontier Medicines (11/04/25)
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  • Senior Principal Scientist , Peptide…

    Genentech (South San Francisco, CA)
    …us Genentech. **The Opportunity** We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist ) to join our innovative ... novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your… more
    Genentech (11/06/25)
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  • Senior Principal Scientist , Pre

    Pfizer (San Diego County, CA)
    **ROLE SUMMARY** This Senior Principal Scientist position will be a strong scientific and leadership role within the Early Formulation Science and Drug Delivery ... and drug delivery systems design + Integrates pharmaceutics, physical organic chemistry , biophysical chemistry , supramolecular chemistry , materials science,… more
    Pfizer (11/19/25)
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  • Principal Scientist , Preclinical…

    Merck (South San Francisco, CA)
    …Pharmaceutical Sciences (DPS) group based in South San Francisco, CA is seeking an Principal Scientist with small molecule and peptide experience. DPS is a ... the progression of clinical candidate selection including Safety Assessment, Process Research, Medicinal Chemistry , Analytical Chemistry , and Drug Metabolism… more
    Merck (11/08/25)
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